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Lipoprotein(a) is associated with left ventricular systolic dysfunction in a Chinese population of patients with hypertension and without coronary artery disease

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Berberine also activates an enzyme called AMP-activated protein kinase (AMPK)

These findings establish a mechanistic link between excessive CGA exposure, cellular iron deprivation, and mitochondrial dysfunction, providing a crucial scientific basis for defining its safe dosage window and understanding its potential hepatotoxic risk under conditions of overdose or highly concentrated exposure

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