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The gut microbiota aids in breaking down complex food components, synthesizing vitamins and short-chain fatty acids, and regulating immune responses

these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

Available online at: 196 Ruiz-RodrguezL.AguilarA.DazA

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This is often the most noticeable during dose increases, and some studies have also reported that heart rate has also increased