Nature (2020) 585(7826):6038
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Requirement for Flk-1/KD.Ractivation
The ELF GSH levels after the rest period was the expected 250 M but when the mice were sacrificed immediately following the third day of CS exposure the ELF GSH levels were no different than control levels unlike the nave mice which CS exposure depleted the ELF GSH levels by 50% (Figure 4A)
It would also need a plan for monitoring side effects and stopping criteria