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Three additional variables accelerate degradation even when refrigeration is maintained: light exposure, freeze-thaw cycles, and contamination during use

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Drug-induced malabsorption: Long-term medications like metformin or proton-pump inhibitors can reduce B12 absorption

Single-cell RNA sequencing analysis identifies enhanced expression of senescence-associated secretory phenotype genes, elevated p16 protein levels, and increased -galactosidase-positive cells in keloid tissue compared to normal skin

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