In practice with GHK-Cu: The copper dose delivered via typical topical or therapeutic administration is modest Short-term use has not been prominently associated with clinically significant zinc depletion Long-term or high-dose use warrants monitoring in patients where zinc balance is clinically important Patients with known zinc deficiency or on zinc-replacement should be monitored more closely A reasonable clinical approach: monitor copper and zinc status in patients on chronic GHK-Cu, particularly in symptomatic or long-duration protocols
Similar to SubQ injections, your prescription may list the amount in mL, units or both
GHK-Cu is a small, naturally occurring copper peptide (a tripeptide, meaning three amino acids: glycine, histidine, lysine) bound to a single copper ion
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Oncogene 23 , 85208526 (2004)
First isolated from human plasma, GHK-Cu is one of the most extensively studied peptides in published research literature, frequently referenced in models exploring skin biology, collagen and elastin signalling, gene expression modulation, and extracellular matrix remodelling pathways
