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These miRNAs regulate the proliferation, differentiation, and apoptosis of chondrocytes, influence the synthesis of the ECM of cartilage, participate in cellular inflammatory responses, and play a significant role in the pathogenesis and progression of OA

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When a random set of parameters is generated, we then examined the generated set of initial parameters and whether they are confined to a steady state of metabolic flux for 24 hours before the glucose administration using the experimentally measured molecule concentrations as the initial values

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