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Author contributions: Carmelo Scarpignato: Conceptualization

Hepatic Detoxification Support: Assists Phase II liver pathways in processing heavy metals and metabolic waste

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Patient-centred models similarly appreciate the significance of psychosocial and quality-of-life end points, such as fatigue, cognitive function, pain, emotional well-being and treatment-related nausea or neuropathy that are commonly endorsed by patients in explaining their motivation to take supplements (236)

Synergy between PI3K/Akt and Raf/MEK/ERK pathways in IGF-1R mediated cell cycle progression and prevention of apoptosis in hematopoietic cells