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The rapid industrialization and urbanization processes are gradually increasing the load of metal and metalloids such as Cd, Pb, Cr, As, Hg, Ni, Cu, Zn, and Co to agricultural soils [2]

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Subsequently, the solution underwent dialysis using a dialysis bag with a molecular weight cutoff of 800014,000 Da

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Interestingly, these seemingly dichotomous effects of E2 on intracellular bioenergetics could be a result of differential receptor activation, as E2 was found to inhibit F0F1-ATP synthase activity via non-genomic mechanisms in a human osteoclastic cell line (FLG 29.1 cells) (200)