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In the trial with semaglutide 1 mg and 2 mg injection for type 2 diabetes mellitus, GI events occurred more frequently among patients receiving semaglutide 2 mg injection (34%) compared to semaglutide 1 mg injection (30.8%)

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#Bioengineering #Organogenesis #MedicalResearch #SyntheticBiology To view or add a comment, sign in From MBoC: Arthur Beyder, Mayo Clinic, explores how sensory enteroendocrine cells integrate calcium and cAMP signaling to translate gut stimuli into hormonal and neural responses

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That means nasal dosing often needs to consider a slightly higher dose (or more frequent spritz) to match systemic exposure from injection