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Although APT2 can also catalyze self-depalmitoylation at Cys2, APT1 and 2 have distinct substrate specificity although why this should be is not yet understood ( in vitro

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Several factors can lead to dysregulation of the ER microenvironment, such as hypoxia, nutrient imbalance, reactive oxygen species, and low PH

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All experiments were performed using SEC-purified ASXL1 EBM-MBH -6His (aa 635564) in 25 mM MES pH 6.8 buffer, 150 mM NaCl, and 3.0 mM DTT