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Its described antinociceptive effect in animals might decrease pain-induced impotence and increase sexual and reproductive function

No case reports have been published on congenital anomalies occurring in the offspring of men receiving methotrexate therapy

NHS laboratories generally define deficiency as a serum B12 below approximately 148 pmol/L (equivalent to roughly 200 ng/L or pg/mL), though reference ranges vary between laboratories and results should always be interpreted in the context of local ranges and the patient's clinical presentation

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