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This is because: GLP-1 agonists: Slow gastric emptying, enhance insulin secretion, regulate hepatic glucose Amylin agonists: Suppress appetite centrally, slow gastric emptying via distinct pathways Together: Complementary mechanisms produce additive/synergistic effects on weight loss Cagrilintide Monotherapy Trials Initial clinical development focused on establishing the safety, tolerability, and efficacy of cagrilintide as a standalone therapy for weight management

The maintenance phase demonstrates whether achieved benefits persist with reduced intensity protocols or whether more aggressive approaches are necessary to sustain improvements

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PMID: 242 PruthiSQinRTerstreipSALiuHLoprinziCLShahTRet al