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HepG2 cells were exposed to synthesized QIs, which bypasses the need for intracellular bioactivation of AQ or DEAQ

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Polyphenol oxidase (PPO) and laccase are both copper enzymes that oxidize phenol using O 2 instead of H 2 O 2

doi: 10.1016/j.cell.2015.11.055 154 WangS.XiaG

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that "ancient genome analysis identified de novo mutations...representing genes involved in cognitive function...and conserved evolutionary selection clusters"