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We also found that auranofin is an efficient inhibitor of pure TGR ( K i = 10 nM), able to kill parasites rapidly in culture at physiological concentrations (5 M), and able to partially cure infected mice (worm burden reductions of ~60%)

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Likewise, larval, skin stage parasites, and juvenile liver stage parasites (unpublished data) are killed in less than 10 h by AF at concentrations as low as 5 M (Figure 6A)

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