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The evolution of GSH in aging fibroblasts showed a sudden increase in its concentration just before cell death, whereas GPx activity was already decreasing at the beginning of passages, and that of glutathione reductase was constant and reaching a very low level at the end of the cell culture, suggesting that the GSH system was probably involved in cell degeneration associated with aging [18]

Negative feedback role of astrocytes in shaping excitation in brain cell co-cultures

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By stabilizing cardiolipin, SS-31 prevents electron leakage at its source, improving ATP generation while reducing oxidative stress

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