Oral administration in neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and rotenone induced rodent models dose-dependently improved motor function, preserved striatal dopamine and tyrosine hydroxylase levels, and reduced DA neuron loss (Maher, 2021
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Moreover, local intracellular accumulation and receptor-independent actions may require higher pharmacological concentrations of melatonin to engage redox-sensitive pathways such as NRF2 compared with approaches which target the central nervous system
Suggested Adult Use: Take 2 capsules daily preferably on an empty stomach, or as recommended by a nutritionally informed physician
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