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In summary, the P2X7R-NLRP3-GSDMD-IL-1 pathway constitutes a unified pathophysiological axis that integrates OS and pyroptosis signals

doi: 10.1146/annurev.pharmtox.010909.105600 31 RuQLiYChenLWuYMinJWangF

Research shows it is good for metabolic health

Future therapeutic strategies should aim to restore redox balance and calcium homeostasis in a manner that also optimizes metabolic efficiency

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