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Abstract Background Preclinical and clinical studies over the past several decades have indicated the potential value of metformin, a widely utilized treatment for Type 2 diabetes, in prostate cancer therapy

Its effects are more gradual and cumulative, working through cellular signaling and tissue remodeling processes that unfold over hours to days

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and Could interventions from exercise and nutrition to precursor supplementation tip the balance back toward resilience

Actual usable doses can be lower because of vial dead volume, syringe or needle dead space, transfer loss, inability to withdraw the final drops, or the beyond-use date arriving first