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Oral glutathione has poor bioavailability because stomach acid and gut enzymes break the molecule apart before it reaches the bloodstream

[Google Scholar] Potters G., Horemans N., Bellone S., Caubergs R.J., Trost P., Guisez Y., Asard H

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This change to the structure extends the half-life to about 170 to 180 hours, which allows for dosing once a week

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