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GSH synthesis is dysregulated in multiple human diseases

Food & Drug Administration (FDA) has not approved glutathione for skin-whitening purposes.[4] While glutathione is widely studied for its antioxidant properties, its use for cosmetic skin lightening is considered off-label

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

Such combined approaches could involve the use of mitochondrial-targeted therapies, antioxidants, and interventions aimed at promoting cellular antioxidant defense mechanisms

Patients with moderate to severe glutathione synthetase deficiency typically have mutations that affect the catalytic properties of the enzyme

Method Enzymol, 186, 100108