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Key factors hindering the healing of diabetic wounds include persistent high level of reactive oxygen species (ROS), excessive inflammatory cells and cytokines in the wound microenvironment, insufficient new blood vessel formation, and weakened cell proliferation 21,22

Western blotting Samples were lysed in RIPA buffer containing a protease inhibitor, and the total protein content was quantified using a bicinchoninic acid protein assay kit (Beyotime)

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Funding This work was supported by funding from the Natural Science Foundation of Hunan Province (No