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IBM is characterized by primary pathological hallmarks, including protein amyloid aggregates in muscle fibers, inflammation, and loss of skeletal muscle 114,251

elucidated the synergistic relationship between metabolic interventions such as the KD and cancer therapeutics, specifically highlighting how glucose restriction potentiates metformins anti-tumor activity through multifaceted mechanisms

249 In addition, caloric restriction has also been shown to delay aging by reducing IgG levels

In another rat experiment, vitamin E has been shown to control hyperglycemia and lower glycated hemoglobin, and HbA1c, by suppressing the oxidative stress level (Ihara et al

Following incubation, the tubes were centrifuged, and the supernatant was transferred to fresh tubes