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Determinants of activity in glutaredoxins: an in vitro evolved Grx1-like variant of Escherichia coli Grx3

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Luckily, our bodies produce these built-in defense mechanisms, but if mounting reactive oxygen species (ROS) cannot be neutralized (picture a small fire that grows out of control when gassed with oxygen), damage ensues

Notably, LLC has been proven to be a highly aggressive and poorly immunogenic tumor model, unresponsive to mono- and bi-modal therapies, such as radiotherapy and immune checkpoint blockade [78]

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