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Signaling properties of structurally diverse kappa opioid receptor ligands: toward in vitro models of in vivo responses

doi: 10.1016/j.jhep.2011.01.006

FDA Guidance Documents

51 Monoamine oxidase (MAO) activates the metabolism of adrenaline and triggers calcium signaling in astrocytes, 52 which suggests that antidepressants may directly affect astrocytes by preventing them from reabsorbing monoamines