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Upon 15 min incubation on ice, cell lysates were cleared by centrifugation for 15 min at 10,000 g and subjected to SDS-PAGE and Western blot analysis

10.1007/s11011-021-00800-w 76 PopracP.JomovaK.SimunkovaM.KollarV.RhodesC

Together, these data identify SLC25A40 as a key regulator that sustains ETC integrity to promote cytokine production, revealing a previously unrecognized role for the SLC25A40-mtGSH axis in coupling mitochondrial redox control to macrophage activation

This can be particularly beneficial for patients with chronic conditions that are exacerbated by toxin accumulation

Early non-specific antioxidants (such as high-dose vitamins) demonstrated highly inconsistent clinical benefits across different studies (115)

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