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Early small trials suggested that TUDCA might slow functional decline in ALS patients, leading to larger studies.38 TUDCA was later tested in combination with sodium phenylbutyrate (marketed as Relyvrio/AMX0035)

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423 Astrocytic atrophy and reduced synaptic coverage might be responsible for hyperactive glutamatergic transmission often observed in BP, especially during mania phases

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Counterstaining was performed by 4,6-diamidino-2-phenylindol (DAPI) (ACD)