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Psychiatry 81 , 442451 (2017)

Eumelanin Firstly, DOPAquinone is converted to leucoDOPAchrome and then DOPAchrome through auto-oxidation, and subsequently in the presence of DOPAchrome tautomerase and dihydroxyindole-2-carboxylic acid oxidase, DOPAchrome is converted to 5,6-dihydroxyindole

74% of the animals lived to 90 weeks

Consistently, Ddit4 Hep mice showed substantial resistance to the AMSCs-induced PGC-1 activation against APAP overdose, as Nrf1 and Tfam mRNA were not upregulated (Fig