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Outside the context of NDDs, the FDA has approved Luxturnaa transgene therapy to deliver the RPE65 gene to the retina and effectively treat a rare inherited retinal disease that results in vision impairment and blindness [48, 49]

Zhu K, Yang S, Li T et al (2022) Advances in the Study of the Mechanism by Which Selenium and Selenoproteins Boost Immunity to Prevent Food Allergies

In preclinical models, BPC-157 is investigated for its activity across several interconnected signaling cascades, including the VEGFR2/eNOS angiogenic axis, the FAK-paxillin pathway in tendon fibroblasts, and ERK1/2-mediated transcription factor activation

However, in conditions of oxidative stress, production of ROS overwhelms antioxidant defense