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Although the theoretical limitations have been addressed, clinical experiments are necessary to validate the findings based on cell and animal studies

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In tumours, extracellular traps released by neutrophils (referred to as NETs) can shape the tumour microenvironment into an immunosuppressive context

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Oxid Med Cell Longev 2019:1681254

On the other hand, adipocytes subjected to oxidative stress express distress factors which are subsequently identified by the cluster of differentiation 8 (CD8), lymphocytes as well as natural killer cells (NK) which will synthesize interferon- (IFN-) inducing the transition of adipose tissue macrophages from the anti-inflammatory (M2) state to the pro-inflammatory (M1) state triggering inflammation [16]