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While peptide therapy is safe for most individuals, it should be avoided by those with untreated active cancers, certain autoimmune conditions, or who are pregnant unless specifically cleared for treatment
Opioid systems play a crucial role in the regulation of pain, with exogenous ligands of opioid receptors being utilized as analgesics for centuries (Pellissier et al
Peripheral neuropathy applications including diabetic neuropathy, chemotherapy-induced neuropathy, and traumatic nerve injuries represent potential indications based on demonstrated nerve regeneration enhancement in animal models
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It should not be used in newborns increased mortality in patients with acute critical illnesses in intensive care units due to complications following open heart or abdominal surgery, multiple accidental traumas, or with acute respiratory failure
Complete tears almost always are treated with surgery
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