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If you eat very little meat, fish, eggs, or dairy or none at all dietary B12 is likely insufficient

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Activation in the area postrema (AP) The area postrema is a circumventricular organ , a region of the brain that has no blood-brain barrier , so peptide hormones from the blood have direct access to it

[DOI] [PMC free article] [PubMed] [Google Scholar] 291.Ye F., Zhan Q., Xiao W., Tang X., Li J., Dong H., Sha W., Zhang X

Low intake of vitamin B12 affects the digestive tract, and a severe deficiency paralyses the muscle tissue in the lining of the digestive tract, hindering intestinal function

Inconsistent daily dosing