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While originally studied for gastrointestinal healing, research has expanded to investigate its potential effects on musculoskeletal tissues, making it a subject of interest in veterinary medicine, particularly for canine orthopedic conditions

The clinical drug development program was halted in 2007 after the pivotal Phase IIb trial did not show statistically significant weight loss in the primary endpoint

Bioavailability & Pharmacokinetics AOD-9604's pharmacokinetics are incompletely characterized, particularly for oral administration

While large-scale human trials are still developing, a small pilot study with 16 patients experiencing knee pain showed promising pain relief with no adverse effects

Free radicals aggressively attack lipids in the cell membranes, a process known as lipid peroxidation, which destroys the structural integrity of neurons and mitochondria alike

Water retention Some puffiness or bloating, especially in hands and face, as IGF-1 causes cells to hold more water