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Untreated deficiency can lead to permanent nerve or brain damage
The small molecule quinolinol MMRi62 has also demonstrated potential in overcoming gemcitabine resistance by promoting the proteasomal degradation of mutant p53 and the lysosomal degradation of NCOA4 and FTH1, ultimately inducing ferroptosis
Limited human clinical trial data Most evidence is preclinical and observational
Zhu W, Zhou Z, Wu C, Huang Z, Zhao R, Wang X, et al
