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Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA)
Oxidative stress is represented in the model by the concentration of H 2 O 2
Intact bacteria, antigens, and particulate matter are transported by specialized M-cells overlying intestinal lymphoid aggregates (Peyers patches) in the distal small intestine [16,17,18] and are sensed by goblet cell-associated antigen pathways (GAPs) [19], with some data indicating that LPS is absorbed through the lamina propria by GAPs in the small intestine [20]
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Thus, gut, brain, and kidney signals, a tripartite communication network, are integrated through multiple signaling mechanisms involving vagal signaling, microbiota-derived metabolites, immune-mediated crosstalk, and neuroendocrine regulation
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