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Enhancement of endogenous antioxidant defense network, such as the nuclear factorE2related factor 2 (NRF2) pathway and antioxidant enzymes, seems more promising, but it also needs to confront the problem of offtarget

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LPS also up-regulates ZIP14 mRNA from primary human macrophages, which acts as a limiting inflammatory response

In May 2003, a draft DoD Instruction 5000.2 on Operation of the Defense Acquisition System cited SBIR/STTR as a source for three key technology-related functions