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These changes drive T cells toward senescence, a state of irreversible cell cycle arrest accompanied by the senescence-associated secretory phenotype, characterized by inappropriate activation, poorer function and enhanced secretion of proinflammatory cytokines such as IL-6, TNF-, and IFN- (Olivieri et al., 2018

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[4] Dimet-Wiley A, et al

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In clinical studies, two beneficial bacterial species, Bacteroides fragilis, have risen while Lactobacillus and Bifidobacterium have dropped significantly