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However, the magnitude of immune modulation is far weaker than biologic drugs like adalimumab, and no long-term human studies have tracked infection rates or immune function markers beyond 12 weeks

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117(6):e57-e66

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SASP (senescence-associated secretory phenotype) results revealed that FOXO4-DRI downregulates the levels of IL-1 , IL-6 , IL-8 , and TNF- (Figure 4H)

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Group 1 received a topically applied liquid NAC oral rinse using a 10% acetylcysteine solution (Mucomyst Solution , Boryung Pharmaceutical Co., Republic of Korea

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Physiological iron deficiency is typically linked to increased demand and inadequate absorption, while pathological iron deficiency may arise from iron malabsorption (such as gastric acid insufficiency or mutations in TMPRSS6 ) or chronic blood loss (due to tumours, gastrointestinal bleeding, or infections), among other causes [61,62,63,64]

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Understanding these mechanisms is crucial for developing effective strategies to combat drug resistance

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