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Phosphorylation is a process that activates or deactivates many protein enzymes and is a crucial step in sending signals within cells

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This finding is particularly relevant because fatty liver disease affects a substantial percentage of people with obesity and can progress to serious conditions like cirrhosis and liver cancer

In addition to the effects of SMAD3 antagonism on MMP9, treatment with both TGF 1 and SIS3 was also able to rescue the downregulation of claudin-5 mRNA and protein (Figures 6a and b) compared with TGF 1 treatment alone