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Vigorous agitation introduces air bubbles and generates mechanical shear forces that denature sensitive peptides

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[Google Scholar] 4.Jha V, Garcia-Garcia G, Iseki K, et al

The frequency and severity of gastrointestinal symptoms can vary depending on the formulation (tablets, sublingual preparations, or liquid forms), the dose administered, and individual patient factors such as existing digestive conditions or sensitivities to inactive ingredients in the supplement

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Yeung, C., Callies, C., Tttelmann, F., Kliesch, S