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As a form of metabolic reprogramming, dysregulated SHMT-mediated one-carbon metabolism has been increasingly reported in various human cancers and liver metabolic diseases

In other words, as the concentration of the analyte increases or decreases, the response of the method should increase or decrease in a linear manner

These competing molecules are removed typically removed through either chromatographic procedure or dialysis

In some embodiments, the otic formulation or composition comprises about 0.4% by weight of the carbomer