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Older uncontrolled or weakly controlled reports describe DSIP administration during opiate- and alcohol-withdrawal protocols [14], but these predate modern addiction-medicine research standards and do not constitute a clinical evidence base

In addition, higher angiotensin II increases MAO-A levels in the heart, arteries, and nervous system.[ref] Varicose veins the enlarged, twisted veins usually seen on legs can be caused by venous insufficiency

Journal of Physiology , 596(17), 4011-4025

Kim et al., 2009)