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(River Peptides) When immune clearance of senescent cells declines with age, their accumulation accelerates organ dysfunction, frailty, age-related disease (cardiovascular disease, osteoarthritis, kidney decline, endocrine decline, etc)

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Rapid proliferation, high protein synthesis rates, hypoxia, nutrient deprivation, acidosis, and oxidative stress collectively impose a severe folding burden on the ER

Cell killing by HIV-1 protease

Occasional separation may occur under certain conditions

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