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This step might involve acid-base catalysis by the active-site cysteinyl thiolate (which could explain an effect of the second cysteinyl residue), and/or the conserved lysine residue, yielding GS in analogy to glutathione transferases (Fig
Glutathione plays a major role in cellular defenses against oxidative and nitrosative stress
PubMed , Toxicological Sciences , vol
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