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Here, we demonstrated that combining system x C blockade with APR-246 at relatively low doses, selectively and synergistically depleted mut-p53 cancer cells of GSH, leading to significant lipid peroxidation and induction of massive apoptosis (Fig

Similarly, ERK (extracellular signal-regulated kinase) and its involvement in melanin synthesis via the ERK/CREB (cAMP response element binding protein) pathway demonstrate how kinases contribute not only to antioxidant defense but also to pigmentation regulation by upregulating MITF and TRP1 69,71

Treatment recommendations are individualized and require medical evaluation

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Genotoxicity of visible light (400-800 nm) and photoprotection assessment of ectoin, l-ergothioneine and mannitol and four sunscreens

Hepatology 1999