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However, instead of having VP64 directly fused to dCas9, Suntag consists of dCas9 fused to a polypeptide chain in which a VP64-GCN4 antibody fusion is bound to each peptideallowing for multiple copies of VP64 to be recruited to a genes promoter [69]

It should be noted that the differences in gene transcription in both duodenum and sigmoid did not remain statistically significant after correcting for multiple testing and therefore should be interpreted with care

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