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Because of its connection to so many aspects of normal human health, b12 deficiency can manifest itself with many symptoms

A reduction in the mRNA level of inflammatory mediators (iNOS, IL-6, IFN-, and TNF-) and increased expression of HSP 70 and 90 and antioxidant proteins such as HO-1, NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi were observed (Park et al., 2020)

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8 Endocrine Reviews (Oxford Academic)HPG-axis cascade: GnRH stimulation of pituitary LH and FSH secretion

Having a deficiency is associated with: Rickets Osteoporosis Cardiovascular disease Cognitive impairments Asthma Cancer Pain or achiness Depression or feelings of sadness Fatigue Muscle weakness Hair loss Getting sick more easily The recommended daily dose of vitamin D for adults is 600 to 800 international units (IU)