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J Cancer 16(8):25032515

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Consistent with its role in regulating mGSH, mitochondrial cholesterol accumulation emerges as a key factor regulating ROS and electrophile detoxification, and hence disease progression by sensitizing to secondary hits such as TNF, hypoxia or toxic amyloid peptides

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In addition, nanoparticle formulations of polysaccharides improve therapeutic efficacy by improving drug bioavailability and reducing toxicity ( Emerging evidences have demonstrated that ferroptosis is involved in the regulatory activities of polysaccharides in cancer