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It should never be administered intravenously by itself , because it contains no salts and is hypotonic

Note that the cited Cortagen studies used intramuscular (10-day) and intraperitoneal (5-day) routes in animals confirm and document the route appropriate to the model you are reproducing [14] [15]

Such reactions are generally mild and resolve within a few days

The FDA added it to injectable semaglutide in January 2025, and it climbs the dose axis like everything else. Burning or tingling skin tracks the dose, not the weight lost, and an active-comparator study put the risk about twice that of another weight-loss drug. The mechanism is unsettled: the tempting "it is the drugs signaling arm" story is ruled out, because the strongest GLP-1 signaler in the class carries no such signal