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All three TGF- isoforms (TGF-1, TGF-2, and TGF-3) are confirmed to regulate EndMT in diabetic kidney disease (DKD), and the latest research has shown that TFPI2 contributes to diabetic renal fibrosis and EndMT by positively regulating the TGF-/Smad signaling pathway [36]

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BPC-157 is currently classified as an FDA Category 2 bulk drug substance, reflecting both its research interest and its regulatory status as a compound under active scientific scrutiny

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