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This increased transmission of pulsatile and high-pressure blood flow into the cerebral circulation is associated with cerebral microvascular damage, which contributes to chronic reductions in CBF seen with aging and disease (Suri et al., 2020)

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3000 x g , 4 C, 10 min), and concentrated 100-fold by ultrafiltration (Amicon, 100 kDa)

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Morphological evidence of any accompanying disease should actively be sought